2-Methyl-4-pyridineboronic acid pinacol ester

2-Methyl-4-pyridineboronic acid pinacol ester - Names and Identifiers

Name	2-Methylpyridine-4-boronic acid pinacol ester
Synonyms	2-aMino-4-pyridine boronic ester 2-Picoline-4-boronic acid pinacolate 2-Picoline-4-boronic acid pinacol ester 2-Methylpyridine-4-boronic acid pinacol 2-Methyl-4-pyridineboronic acid pinacol ester 2-Methylpyridine-4-boronic acid pinacol ester 2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-METHYL-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE
CAS	660867-80-1
InChI	InChI=1/C12H18BNO2/c1-9-8-10(6-7-14-9)13-15-11(2,3)12(4,5)16-13/h6-8H,1-5H3

2-Methyl-4-pyridineboronic acid pinacol ester - Physico-chemical Properties

Molecular Formula	C12H18BNO2
Molar Mass	219.09
Density	1.02
Melting Point	66-71°C
Boling Point	315.9±30.0 °C(Predicted)
Flash Point	144.8°C
Solubility	soluble in Methanol
Vapor Presure	0.000788mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
pKa	5.11±0.10(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.489
MDL	MFCD08061590

2-Methyl-4-pyridineboronic acid pinacol ester - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.

2-Methyl-4-pyridineboronic acid pinacol ester - Introduction

2-Methylpyridine-4-boronic acid pinacol ester is an organic compound with the chemical formula C12H19BNO2. It is a white crystalline solid with a peculiar smell. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
-Appearance: White crystalline solid
-Molecular weight: 217.10g/mol
-Melting Point: 48-52°C
-Boiling Point: No data available
-Solubility: Soluble in most organic solvents such as ethanol, dimethylformamide and dichloromethane

Use:
- 2-Methylpyridine-4-boronic acid pinacol ester is an organoboron reagent, commonly used in the field of organic synthesis. It can be used as reducing agent, catalyst and raw material.
-It can be used to synthesize pyridine and other compounds containing pyridine ring.
-It is widely used in Suzuki-Miyaura coupling reactions for the synthesis of aromatic compounds and heterocyclic compounds.

Preparation Method:
- 2-Methylpyridine-4-boronic acid pinacol ester can be prepared by the esterification reaction of 2-methylpyridine and 4-piperidine-1-boronic acid. Pinacol is used as the esterification reagent during the reaction.

Safety Information:
- 2-Methylpyridine-4-boronic acid pinacol ester has low toxicity under correct operating conditions.
-In use, should follow the general laboratory safety procedures.
-Avoid direct contact with skin and eyes, and make sure to use it in a well-ventilated place.
-Try to avoid inhaling its gas or dust.
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-10 22:29:15